Biogenic amine signaling in the brain
Emerging evidence reframes biogenic amines, traditionally known for their roles in neurotransmission, as chemical donors for key protein post-translational modifications that shape cellular signaling and transcription.
Histone monoaminylations, such as H3 Gln5 serotonylation, dopaminylation, and histaminylation, represent a novel epigenetic class influencing molecular and behavioral phenotypes.
Transglutaminase 2 installs, removes, and exchanges these modifications, thereby regulating neural transcription, development, and plasticity.
Advances in chemical biology are expanding the repertoire of monoaminylated proteins in the brain, revealing their critical roles in modulating neural function and plasticity.
https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(25)00241-3
