GABA signalling networks in the brain–gut–microbiome axis
Gut microbiota metabolites and classical neurotransmitters have been implicated in brain–gut–microbiome (BGM) axis. However, GABA's role within the BGM axis had received limited attention.
The researchers explore the role of GABA in integrating brain and GI tract functions.
They discuss how gut bacteria use and produce GABA, influencing brain activity and providing potential therapeutic opportunities for brain disorders.
GABAergic signalling, via different receptor subtypes, directly regulates BGM homeostasis by modulating the excitability of neurons within brain centres responsible for gastrointestinal (GI) function in a sex-dependent manner, potentially revealing mechanisms underlying the greater prevalence of GI disturbances in females.
They also discuss how diverse group of cell types, including enteric neurons, glia, enteroendocrine cells, immune cells and bacteria, integrate peripheral GABA signals to influence brain functions and potentially contribute to brain disorders.
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awae413/7931903
https://sciencemission.com/GABA-signalling-networks-in-the-brain%E2%80%93gut%E2%80%93microbiome-axis
