New tool identifies drug targets to stop cancer treatment resistance
Complex resistance mechanisms come in to play after cancer treatment with variety of drug combinations,
In this study, the researchers introduce a graph embedding computational pipeline (RECODR) that measures changes in gene co-expression context during cancer treatment.
RECODR enables the design of highly effective combination treatments for aggressive brain tumors in mice and the prediction of potential new treatments for patients with medulloblastoma and triple-negative breast cancer.
https://www.cell.com/cancer-cell/fulltext/S1535-6108(25)00255-7
