Neuronal functions of actin regulator, cyclase-associated protein
Cyclase-associated protein (CAP) acts as a key regulator of actin dynamics and dysregulation of CAP has been associated with human brain disorders.
Neuronal functions of CAP are not clearly understood but recent studies have indicated CAP-dependent mechanisms in neuron differentiation or synapse morphogenesis.
Studies have shown that CAP1-KO in neurons cause an increase in growth cone size and an altered growth cone morphology.
Studies have also shown that in CAP1-KO neurons, dendritic spine shrinkage associated with long-term depression (LTD) is impaired.
Postsynaptic CAP2 levels and CAP2 dimerization is reduced in patients with Alzheimer’s disease (AD) and mouse models.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00029-7
