Sleep deprivation in Alzheimer model
Aging is often linked to sleep loss, which, often precedes the onset of Alzheimer’s disease.
The researchers compared sleep deprivation in young wild-type mice and their APP/PS1 littermates, a murine model of Alzheimer’s disease.
They report that sleep loss suppresses NREM norepinephrine oscillations in a murine model of Alzheimer’s disease along with a parallel buildup of amyloid-b. However, norepinephrine oscillations persisted in wild-type mice after sleep deprivation.
Thus, overexpression of amyloid-b inhibits recovery sleep and thereby slows glymphatic protein clearance after sleep deprivation.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01328-7
