The role of cytokine receptor Fn14 in adult brain
The cytokine receptor Fn14 previously been shown to be involved in the refinement of visual circuit connectivity between the retina and the dorsal lateral geniculate nucleus (dLGN) of the thalamus but its role in mature brain function is not known.
The researchers show that Fn14 is induced by neuronal activity environmental enrichment in neurons of CA1, where it recruits rod-like microglia to synapses and dampens neuronal activity.
Fn14 expression is regulated by the circadian transcription factor Bmal1, consistent with circadian cycle length and sleep-wake states being altered in mice lacking Fn14.
Mice lacking Fn14 also exhibit heightened susceptibility to chemically induced seizures.
https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00004-5
