deta-GABAA receptors in adult mouse gustatory cortex control sweet preference

It is well established that the gustatory cortex (GC) is engaged in taste perception, palatability, and preference but the neural and neurochemical signals regulating taste preference is not well understood.

dGABA_ARs produce a tonic inhibitory current and are widely distributed in the brain their expression within gustatory circuits and their role in taste preference has not been investigated.

.The researchers demonstrate that sensitivity and preference for sucrose in adult mice are modulated by tonic inhibitory currents mediated by neurosteroid-sensitive dGABA_ARs within the GC.

They show that dGABA_ARs are expressed in multiple cell types within GC, mediate an allopregnanolone (ALLO)-sensitive tonic current, decrease the behavioral sensitivity to sucrose, and reduce the preference for sweet taste in a cell-type-specific manner. 

https://www.cell.com/current-biology/fulltext/S0960-9822(25)00065-X

https://sciencemission.com/d-GABAA-receptors-in-mouse--gustatory-cortex