How ergothioneine improves healthspan of aged animals

A dietary thione/thiol, ergothioneine, has been shown to have healthy benefits in aging but the mechanism is not clearly understood.

. The researchers demonstrate that ergothioneine acts as an alternative substrate for cystathionine gamma-lyase, an H2S-producing enzyme, leading to an increase of protein persulfidation.

The persulfidation of cGPDH enhances its activity, resulting in a boost of NAD+ levels.

Treatment with ergothioneine improves healthspan and physical performance in aged animals.

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00490-X

https://sciencemission.com/Ergothioneine-improves-healthspan