Health benefits of exercise-induced extracellular mitochondria
Health benefits of exercise is thought to be mediated in part by exerkines.
Health benefits of exercise also involve the remodeling of mitochondria in multiple organs, but the impact of exercise on circulating extracellular –Mito (exMito) is poorly understood.
Extracellular mitochondria have recently been suggested as a player in mediating intercellular communication. The cellular origin of exercise-induced circulating ex-Mito and the role of each form (vesicle-enclosed, free, or as mitochondrial components) in mediating exercise's therapeutic effects are yet to be elucidated.
The researchers in this review discuss the role of ex-Mito as potential players in exercise-related health benefits, including the role of mitochondrial transfer and transplantation in non-pharmacological therapeutics.
https://www.sciencedirect.com/science/article/pii/S0300908425003165
