Rat model for familial Parkinson’s disease
The researchers report on the first Parkinson’s α-synuclein mutation rat model.
Familial Parkinson’s disease is linked to point mutations in the SNCA gene, which encodes α-synuclein (αSyn).
A single glycine-to-aspartic acid change at codon 51 in the SNCA gene using CRISPR/Cas9 gene editing, reduced localization of αSyn to synapses and increased Lewy pathology acquisition.
Stereotaxic delivery of αSyn pre-formed fibrils (PFFs) into the pre-frontal cortex showed discrete Lewy pathology-like structures positive for phosphoserine-129-αSyn (pS129-αSyn) only in SncaG51D/G51D brains at an early time-point of 6 weeks post-injection.
https://academic.oup.com/braincomms/article/7/3/fcaf224/8157954
https://sciencemission.com/Glycine-to-aspartic-acid-mutation
