Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer’s pathology
Neuronal loss and cognitive decline in Alzheimer’s disease is been attributed to neurofibrillary tangles (NFT).
The researchers used two-photon microscopy to test this hypothesis and track the neurofibrillary tangle (NFT) formation and neuron loss in model mice.
They observed that neurons with NFTs died less frequently than neurons without NFTs. They found neurons without tangles died at >3 times the rate as neurons with tangles.
Dying neurons could also be identified by local cortical microstructure changes, providing a method to identify susceptible populations.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00903-3
