New genetic risk for severe macular degeneration revealed
Researchers have for the first time pinpointed specific genetic changes that increase the risk of severe, sight-threatening forms of age-related macular degeneration (AMD).
A new study, published in Nature Communications, reveals the specific genetic factors linked to the presence of reticular pseudodrusen (RPD) - deposits which drive vision loss and are found on the retina of up to 60 per cent of people with advanced AMD.
The research offers a promising new target for treatments aimed at the most severe forms of AMD, including geographic atrophy.
AMD is a leading cause of irreversible blindness in people over 50 worldwide, resulting from the death of light-sensing cells in the macula, the part of the retina needed for central vision.
Globally, more than 196 million people have AMD. In its early stages, it is difficult to predict who is most at risk of vision loss and when treatment should begin. Current therapies can only slow disease progression once significant damage has occurred.
The team led a large international study which, for the first time, pinpointed a key difference in genetic changes in the group with RPD – finding a strong link with genetic variations on Chromosome 10 but no link to other well-known AMD genes changes on Chromosome 1.
The chromosome 10 RPD risk region contains a long non-coding RNA HTRA1-AS1 (ENSG00000285955/BX842242.1) which colocalizes with genetic markers of retinal thickness. HTRA1-AS1 has a strong retinal eQTL signal, pinpointing the parafoveal photoreceptor outer segment layer.
Eye scans of people with this genetic variation also revealed a thinner retina, a finding that warrants further investigation.
Study co-lead said the results highlight that AMD is not a single disease but a group of related conditions potentially requiring tailored treatment approaches.
“Reticular pseudodrusen deposits, visible in eye scans, have been linked to worse visual function and poorer treatment outcomes,’’ the author said.
“Our research has now identified which of the genetic changes appear to be driving this more serious form of AMD. This discovery provides a crucial lead for developing new drugs that target these changes—potentially preventing vision loss before it begins.”
Co-lead said this was the first genome-wide analysis of the genetic drivers behind reticular pseudodrusen.
“In 2005, researchers first linked changes on Chromosome 1 including the complement factor H (CFH) gene, part of the immune system, to AMD,’’ the author said. “Recently, new treatments targeting these changes have shown modest success in slowing down the disease.
“Our study is the first to suggest that reticular pseudodrusen deposits are driven by pathways associated with Chromosome 10 but not by the well-known AMD-related genes on Chromosome 1.
“This is a significant finding. It demonstrates the need to explore how genetic changes on Chromosome 10 affect retinal structure and to develop therapies that go beyond complement factor to targeting to prevent sight-threatening deposits on the retina.”
https://www.nature.com/articles/s41467-025-65903-9
https://sciencemission.com/HTRA1lncRNA-HTRA1-AS1-dominates-in-age--related-macular-degeneration
