Role of glutamate in adipose lipolysis in insulin resistance

A key feature of insulin resistance is the loss of control of lipolysis in adipose tissue, the mechanisms of which remain incompletely understood. 

Recent in vivo tracing studies have revealed a diversion of glucose to glutamate in white adipose tissue during insulin resistance.

Mitochondrial redox imbalance has emerged as a feature of adipose insulin resistance across multiple in vitro and in vivo models.

A key regulator of adipose lipolysis is neurometabolic signalling, yet many commonly used experimental models lack intact innervation.

These observations motivate an exploration of how altered adipocyte metabolism contributes to dysregulated lipolysis and how it can be modulated to improve metabolic health.

https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(26)00177-3

https://sciencemission.com/glutamate-an-adipose-redox-signal