A human gut bacterium powerplay with the neighboring bacteria
Microbial antagonism shapes the gut microbiome.
The researchers identify a mechanism used by human gut commensals to antagonize related bacteria.
They show that secreted effector Bte1 targets the PpiD-YfgM periplasmic chaperone complex causing substrate aggregation and toxicity.
Metagenome analysis reveal diverse effector alleles, highlighting an arms between Bte1-encoding and immunity-encoding strains in human gut.
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(25)00026-5
https://sciencemission.com/gut-bacterium-antagonizes-neighboring-bacteria
