How hyperlipidemia may lead to stroke?

The transient receptor potential channel melastatin 2 (TRPM2) plays a critical role in endothelial injury, immune cell activation, and neuronal death but its role in hyperlipidemia is not clear.

The researchers reveal that, in humans, TRPM2 expression in peripheral leukocytes strongly correlates with plasma lipid levels.

Hyperlipidemia-induced TRPM2 upregulation drives abnormal leukocyte activation, compromising vascular and neuronal resistance to ischemia.

TRPM2 inhibition or cell-specific knockouts in myeloid and endothelial cells mitigate hyperlipidemia-aggravated stroke in mice.

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00071-0

https://sciencemission.com/TRPM2-overactivation-and-hyperlipidemia