Driving liver inflammation in MASH via multiple pathways
Metabolic dysfunction-associated steatohepatitis (MASH) if not treated early, may lead to liver cirrhosis and hepatocellular carcinoma (liver cancer).
Hepatic lipotoxicity, intestinal dysbiosis, and pro-inflammatory diets have been attributed to the development of MASH. Moreover, obesity- induced adipose tissue inflammation also contributes to MASH.
The researchers in this review unravel complex, multiple parallel inflammatory mechanisms in MASH and describe how MASH drugs exert their effects.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(26)00087-2
