How maternal vitamin D affects intestinal inflammation in offsprings
Children with ASD exhibit gastrointestinal comorbidity symptoms and have a higher susceptibility to IBD but the mechanisms and prevention of gastrointestinal immune dysfunction remain unclear.
In this study, rodent models were used to demonstrate that maternal VitD reshapes the immune status of offspring via IFN-γ and IL-17A. Offspring exposed to dual insult of maternal inflammation and VitD deprivation show increased susceptibility to intestinal inflammation.
Maternal high vitamin D (VitD) level can rescue abnormal intestinal immune phenotypes in offspring that exhibit autism-like phenotypes due to exposure to maternal inflammation by altering chromatin accessibility and metabolic patterns of CD4+ T cells.
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00628-X
