Stem cell aging hallmarks
Somatic stem cells to lose sustain tissue homeostasis and support regeneration is lost with age.
Stem cells are also vulnerable to both intrinsic and extrinsic stressors.
The researchers in this review delineate five cardinal features that characterize aged stem cells and examine how these alterations underlie functional decline across well-studied stem cell compartments.
The authors discuss how these hallmarks provide insight into the aging process and might act as targets for therapeutic strategies for stem cell rejuvenation and extend the life span.
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00226-7
