MicroRNA regulation of enteric nervous system development and disease
MicroRNAs (miRNAs) serve as key regulators of enteric nervous system development, orchestrating migration, proliferation, and differentiation of enteric nervous system progenitors.
Aberrant miRNA expression underpins the pathogenesis of several enteric neuropathies, including Hirschsprung’s disease.
A convergence of miRNA activity across distinct enteric neuropathies highlights shared molecular pathways, exemplified by the miR-200 family.
Modulating the expression of miRNAs to influence their associated gene expression networks has therapeutic potential for enteric neuropathies.
https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(25)00035-9
https://sciencemission.com/MicroRNA-regulation-of-enteric-nervous-system-development-and-disease
