Immunomodulatory microneedle patch for cardiac repair!
The study introduces a hyaluronic acid hydrogel-based microneedle patch embedded with IL-4-loaded PLGA microparticles for targeted immunomodulation in both rat and porcine models of myocardial infarction.
This biodegradable patch enables sustained IL-4 release, promoting a proreparative immune environment, encouraging cardiomyocyte proliferation, and improving cardiac function in both rat and pig models.
This bioengineered system offers a promising translational platform for cardiac immunomodulatory therapy.
https://www.cell.com/cell-biomaterials/fulltext/S3050-5623(25)00143-6
https://sciencemission.com/Immunomodulatory-microneedle-patch-for-cardiac-repair
