The roles of mitochondria in global and local intracellular calcium signalling

Cytoplasmic calcium ([Ca2+]c) signals generated by the activation of Ca2+ channels in Ca2+ stores in organelles and the plasma membrane control various cellular functions. 

Mitochondria do not store Ca2+ in a prolonged manner under physiological conditions and lack the capacity to generate global [Ca2+]c signals although they have a high capacity for Ca2+ uptake and chelation, and efficient Ca2+ release mechanisms.

Mitochondria accumulates Ca2+ based on high local and neighbouring organelles signals and results in the stimulation of  oxidative metabolism. Thus, the mitochondrial handling of [Ca2+]c is of physiological relevance. Also, dysregulation of mitochondrial Ca2+ handling can contribute to debilitating diseases.

The authors discuss the mechanisms and relevance of mitochondria in local and global calcium signals.

https://www.nature.com/articles/s41580-024-00820-1

https://sciencemission.com/mitochondria-in-calcium-signalling