New type of cancer vaccine!

Inadequate immunogenicity prevented the development of whole tumor cell vaccines using traditional inactivation methodology.

The researchers show a cancer vaccine through the intracellular gelation of tumor cells, combined with CD47 blockade and damage-associated molecular pattern (DAMP) exposure.

The authors demonstrate that intracellular hydrogelation preserves the morphology and antigenicity of tumor cells. CD47 blockade and DAMP exposure synergistically enhance the “eat me” signals and inhibit the “don’t eat me” signals on tumor cells, significantly improving their immunogenicity.

The vaccine reduced regulatory T cells and T cell exhaustion, and elicited a robust tumor-antigen-specific T cell response.

This strategy demonstrates the ability to prevent tumorigenesis, effectively treats early-stage tumors, and improves survival rates in established tumors in combination with check-point inhibitors, highlighting its potential for clinical antitumor applications.

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00165-X

https://sciencemission.com/Cancer-vaccine-from-intracellularly-gelated-tumor-cells