Where mucosal innate immune memory encoded?
Innate immune memory at mucosal barriers extends beyond classical myeloid training and involves multiple immune and structural cell populations.
Inflammatory memory at barrier tissues may be encoded across several compartments, including hematopoietic progenitors, tissue-resident immune cells, structural cells, neuronal circuits, and the local tissue niche.
Environmental signals such as microbiota, infection, and diet may shape mucosal immune memory, influencing both protective host defense and chronic inflammatory disease.
Defining the cellular location and mechanisms of innate immune memory remains a major challenge and requires experimental approaches that integrate techniques such as fate mapping, adoptive transfer, and tissue-specific perturbation.
https://www.cell.com/trends/immunology/fulltext/S1471-4906(26)00293-0
