fMRI evaluation of neuro-glio-vascular signaling

High-resolution rodent functional magnetic resonance imaging (fMRI) enables vessel-specific hemodynamic mapping, capturing changes in cerebral blood volume, flow, and oxygenation at the level of individual penetrating arterioles and venules. 

This ‘single-vessel’ fMRI approach bridges findings from imaging methods with higher spatiotemporal resolution, offering a translational platform to better interpret the vascular origin of fMRI signals observed in human brains.

Combining fMRI with neurotechniques, such as optogenetics or chemogenetics, along with simultaneous electrophysiological recordings or fiber photometry, enables cross-scale brain dynamic mapping of brain activity and neurovascular coupling.

Multimodal rodent fMRI enables the dissection of contributions from local excitatory and inhibitory neural networks, neuro-glio-vascular interactions, and neuromodulatory systems, to fMRI signals across different brain areas.

https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(24)00254-6

https://sciencemission.com/neuro-glio-vascular-signaling-using-fMRI