Outer radial glia promotes white matter regeneration after neonatal brain injury
Outer radial glia (oRG) is populated in outer subventricular zone (OSVZ), but the role of oRG during postnatal development is not well understood.
The researchers demonstrate that postnatal oRG cells enhance their proliferative capacity after neonatal brain injury via upregulation of the ATF5 pathway, promoting the production of OSVZ derived OPCs.
Intranasal activation of ATF5 fosters oligodendrogenesis, leading to white matter regeneration and functional recovery.
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00059-X
