Tools and principles of organellar mechanotransduction
Organelles are exposed to mechanical forces under various conditions.
Recent techniques allow researchers to determine the mechanical properties of organelles and to directly manipulate forces exerted on the organelles.
There are two modes of organellar mechanotransduction: mechanobiochemical coupling and mechanoelectrical coupling.
Mechanotransduction of the endomembrane system involves intricate biochemical signaling cascades.
Various channel proteins mediate the mechanosensitive ion flux across the membranes of the endoplasmic reticulum (ER) and endolysosomes.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(24)00279-4
