Technology for accurate and efficient profiling of the human gut virome

Gut virome analysis is limited by tools that struggle with viral diversity and novelty. 

The researchers present SinProVirP, a signature-protein-based profiler that accurately quantifies known and novel viruses with high efficiency, enabling large-scale, cross-cohort studies of the virome’s role in health and disease.

The technology achieved benchmark accuracy with >80% reduction in computational demand and captured novel viruses with >80% recall, outperforming existing methods.

The method revealed virome dysbiosis in IBD and improved disease classification models.

https://www.cell.com/cell-reports-methods/fulltext/S2667-2375(25)00286-3

https://sciencemission.com/profiling-of-the-human-gut-virome