Human spinal cord enhancer dynamics and cellular architecture
The researchers present an innovative framework redefining human spinal cord cellular diversity through epigenetic configuration and spatial organization.
They identify unseen enhancer classes that define both stable cell-type identity and transitions between cells undergoing differentiation.
The authors also identify gene regulatory networks in glial cells that reorganize along the rostrocaudal axis, demonstrating anatomical differences in gene regulation.
The researchers demonstrate spatial organization of cells into distinct cellular networks and address the functional significance of this observation in the context of paracrine signaling.
