How viruses try to avoid cGAS-STING pathway

The cyclic GMP-AMP (cGAMP) synthase (cGAS) and stimulator of interferon genes (STING) pathway, conserved from bacteria to humans, mediates potent viral resistance. 

The cGAS-mediated viral sensing system operates across multiple cellular compartments, including plasma membranes, the cytosol, and the nucleus.

Multiple viruses have evolved convergent, divergent, and conserved evolutionary means of evading the cGASSTING-mediated host defense pathway.

The evolutionary arms race between host antiviral defenses and viral immune evasion mechanisms presents novel opportunities for therapeutic intervention.

https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(25)00185-3

https://sciencemission.com/Viral-evasion-of-cGAS-STING-pathway