A role for oligodendrocyte transcription factor 1 (Olig1) in promoting axon regeneration
The molecular mechanisms underlying the heterogeneity in regenerative potential of injured axons have not been fully elucidated.
The researchers develop a method that can isolate spinal motor neurons with different regenerative capability after injury and reveals factors with differential expression.
They focus on the functional analysis of Olig1, a transcription factor that determines early neural patterning, and reveal its effects on axonal regeneration in various models.
The authors demonstrate that Olig1 down regulation or knockdown attenuates axonal regeneration and mTOR signaling,
Mechanistically Olig1 promotes axon regeneration through the neurite extension factor 1 (Nrsn1).
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00843-X
