Glucagon promotes increased hepatic mitochondrial oxidation in humans with fatty liver disease
It is unclear whether rates of hepatic mitochondrial oxidation are altered in individuals with MASLD and MASH.
The researchers show that rates of hepatic mitochondrial oxidation are not altered in humans with fatty liver or steatohepatitis and that glucagon can increase rates of hepatic mitochondrial oxidation in humans with and without fatty liver by 50%–75%.
The authors also found an ∼30% increase in rates of mitochondrial pyruvate carboxylase flux with glucagon.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00325-5
