How microglial APOE3 Christchurch protects neurons in Alzheimer’s disease
Amyloid plaque and neuronal Tau tangle agrégation are the hallmarks of Alzheimer’s disease.
The researchers looked into the mechanism of APOE3 Christchurch (APOECh) mediated neural protection.
They demonstrate that APOECh microglia protect neurons from Ab-induced Tau pathology by regulating lipid peroxidation and phagocytosis.
They also show that an APOE mimetic peptide can mimic the protective effects of APOECh microglia.
Thus, targeting APOE and lipid metabolism in microglia represents a promising therapeutic strategy for Alzheimer’s disease.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01333-0
