How sleeping rhythms drive brain detox
During sleep waste products are removed from the brain using glymphatic system but what drives brain clearance during sleep is not clearly understood.
The authors show that arterial oscillations act as a pump driving CSF into the brain.
They also demonstrate that norepinephrine release from the locus coeruleus drives slow vasomotion in NREM sleep and thus, norepinephrine oscillations control opposing changes in blood and CSF volumes.
The sleep aid zolpidem suppresses norepinephrine oscillations and glymphatic flow.
https://www.cell.com/trends/immunology/fulltext/S1471-4906(25)00034-1
