Real-time, multiscale ATP imaging in living mice
The researchers present the AVID mouse, which enables real-time, multiscale imaging of ATP dynamics in vivo across organs and cell types.
This platform reveals spatially heterogeneous changes in energy metabolism during both physiological conditions and pathological states such as myocardial infarction, enabling systems-level analysis of metabolic regulation.
AVID revealed previously undetectable localized ATP depletion near the central vein of the liver after myocardial infarction, spatially linked to kynurenic acid accumulation—a phenomenon invisible to conventional bulk metabolomics.
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01017-4
