Astrocyte reprograming at the border of spinal cord injury or stroke
The features of astrocytes surrounding CNS lesions are unclear.
Here the authors show that after spinal cord injury or stroke in mice, mature astrocytes dedifferentiate, proliferate and are reprogrammed to adopt features of wound repair cells and form borders, re-establishing CNS integrity.
The researchers found downregulation of molecules associated with astrocyte– neuron interactions and upregulation of molecules associated with wound healing, microbial defense and interactions with stromal and immune cells.
