Protecting renal ischemia-reperfusion injury using microbiota

Although the gut microbiota and their metabolites are closely associated with renal ischemia-reperfusion injury (IRI) following kidney surgery, the exact mechanisms are not well understood.

The researchers report that Eubacterium limosum, a gut symbiont, releases ursodeoxycholic acid (UDCA) to suppress renal IRI progression and supplementation with either E. limosum or UDCA prevents mice from IRI.

Mechanistically, UCDA promotes PPARγ activity and increases fatty acid oxidation, inducing ATP production and reducing lipid accumulation in proximal tubular epithelial cells, ultimately protecting the kidney against IRI.

The authors also demonstrate that renal IRI in patients markedly lowers their serum UDCA, patients with higher pre-IRI UDCA or E. limosum level develop less severe IRI.

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00446-X

https://sciencemission.com/Gut-symbiont-derived-UDCA-promotes-FAO