Astrocytic ATP dynamics encode injury information
Although earlier evidence suggests the existence of intrinsic processes that encode and transmit injury information, the molecular mechanism of injury information encoding is unclear.
Here, the authors show that astrocytic ATP dynamics, Inflares, encode injury information and trigger microglia response affecting the tissue damage and recovery of function following injury in mice. Mismatches between Inflares and injury severity lead to microglia dysfunction and worsening of injury outcome.
The researchers show that blocking Inflares in ischemic stroke in mice reduces secondary damage and improves recovery of function.
