Blocking Mycobacterium tuberculosis replication
The researchers report that Mycobacterium tuberculosis (Mtb) infection results in the release of neutrophil extracellular traps (NETs) that promote Mtb replication and associate with tissue damage but the regulation and impact of NET release on Mtb pathogenesis are unknown.
The researchers show that during Mycobacterium tuberculosis (Mtb) infection PAD4 citrullinates histones to decondense chromatin that gets released as NETs in a manner that can maintain neutrophil viability and promote Mtb replication.
Type I interferon promotes the formation of chromatin-containing vesicles that allow NET release without compromising plasma membrane integrity and this model is supported by the anyalysis of nonhuman primate granulomas,
Blocking NET release results in better control of Mtb replication, revealing a strategy for treating these deadly infections.
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00439-6
