High-fat diet impairs ILC3 functions and gut homeostasis

Early events preceding the development of gut inflammation following prolonged exposure to a high-fat diet (HFD) is not well defined.

The researchers report that short-term, high fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis.

IL-22 production by group 3 innate lymphoid cells (ILC3s) is impaired, compromising gut barrier integrity within 48hrs after high-fat diet intake.

Saturated fatty acids intrinsically suppress ILC3 function, reducing their ability to control gut inflammation.

https://www.cell.com/immunity/fulltext/S1074-7613(25)00136-0

https://sciencemission.com/high-fat-diet-impairs-ILC3-functions