Brain metastasis evolution over the years
The field over the last several years has undergone transformative advances, reshaping both the scientific and the clinical landscape.
This review focuses on the pivotal discoveries that have propelled this progress, including omics strategies, the tumor microenvironment, metabolism, experimental models, technological advances, and therapeutic progress.
There have seen a substantial increase in the number of clinical trials specifically including patients with brain metastases (BrMs), with emerging efforts in preventive strategies, antibody–drug conjugates, immunotherapy, and qualityof-life interventions.
This review captures the transition from foundational understanding to meaningful clinical applications.
The advances the authors highlight here chart a path forward for innovative therapeutic strategies with the potential to significantly improve outcomes for patients with BrMs.
https://www.cell.com/trends/cancer/fulltext/S2405-8033(25)00281-X
