Senescent neutrophils and cancer progression

Neutrophils have numerous functions in promoting cancer formation, progression, and metastasis.

Novel neutrophil subsets, such as neutrophil progenitors and senescent neutrophils, contribute to significant myeloid heterogeneity in the tumor microenvironment.

Senescent neutrophils have been identified as a long-lived, protumoral neutrophil population that mediates immune suppression and therapeutic resistance.

A dual approach of inducing senescence in tumors, followed by targeting senescent neutrophils with 'immune senolytics', provides a promising new avenue for therapy in cancer.

https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(24)00187-9

https://sciencemission.ayurmatrika.com/Senescent-neutrophils:-a-hidden-role-in-cancer-progression