Chronic nitric oxide (NO) donor treatment for epilepsy
The researchers show that the level of nNOS declines in the hippocampus of patients with epilepsy.
Selective deletion of nNOS in interneurons of hilus causes epileptogenesis and replenishment of nNOS in the DG blocks epileptogenesis and memory deficits.
The authors demonstrate that the chronic NO donor treatment prevents epileptogenic development.
https://www.embopress.org/doi/full/10.1038/s44321-024-00168-1
