Exercise induced histaminergic crosstalk in human skeletal muscle microenvironment
The researchers identified a role for mononuclear cells in the skeletal muscle microenvironment to steer the response to exercise.
Mast cells locally secrete histamine during exercise, triggering activation of H1 and H2 receptors on myeloid and vascular cells, thereby affecting the exercise-induced metabolic and transcriptional adaptive response.
The authors show that blockade of histamine H1 or H2 receptor in humans that this paracrine histamine signaling cascade drives muscle glycogen resynthesis and coordinates the transcriptional exercise response.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00493-5
https://sciencemission.com/skeletal--muscle-exercise-histamine
