Controlling ferroptosis sensitivity!
The researchers highlight peroxiredoxin 6 (PRDX6) as a critical regulator of ferroptosis.
As a selenium-acceptor protein, PRDX6 aids in intracellular selenium utilization for efficient selenoprotein biosynthesis, including glutathione peroxidase 4 (GPX4), the guardian of ferroptosis.
PRDX6- deficiency reduces GPX4 expression levels in the mouse brain and increases tumor sensitivity to ferroptosis, underscoring its physiological significance.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00868-2
