Hydrogen sulfide-mediated persulfidation and ferroptosis in non-small cell lung cancer
The researchers show that H₂S sensitizes NSCLC cells to ferroptosis through cysteine persulfidation of S-adenosyl homocysteine hydrolase, reducing its activity.
This leads to decreased levels of homocysteine, cysteine, and glutathione, promoting ferroptosis, particularly in low cystine conditions.
These results suggest H₂S enhances ferroptosis-based treatments for NSCLC.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00731-7
