Proteostasis in cellular dormancy

Cell dormancy is a conserved, reversible state of prolonged cellular low activity that involves cell cycle arrest and cessation of growth. In mammals, it preserves adult stem cells for tissue homeostasis and oocytes for reproduction. 

Recent findings highlight oocytes as a fundamental model to study proteostasis during dormancy.

Dormant cells share common characteristics such as low mTOR (mechanistic/ mammalian target of rapamycin) activity, low protein translation, and long-term attenuation of protein degradation.

Low protein degradation causes dormant cells to accumulate protein aggregates, which are sequestered in specialized compartments and cleared upon activation.

https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(25)00108-2

https://sciencemission.com/Proteostasis-in-cellular-dormancy