Crosstalk between the nucleus and ion channel-mediated mechanosensation
The nucleus is a key cell mechanosensor of the local microenvironment.
Nondestructive nuclear mechanosensation responses in confinement involve the build-up of the nuclear lamina, nuclear pore complex stretching-dependent exchange of nuclear–cytoplasmic constituents, and nuclear pressurization.
Destructive nuclear mechano-responses include the nuclear depletion of DNA repair factors and nuclear influx of TREX1 exonuclease, which promote DNA damage, as well as the cytoplasmic access of double-strand (ds)DNA, which can trigger a cyclic GMP-AMP synthase pathway/stimulator of interferon genes (cGAS/STING) response.
Ion channels are among the first molecules to sense and respond to different physical stimuli, including confinement, by regulating intracellular ionic concentrations and water fluxes, thereby altering cell motility.
The crosstalk between nuclear mechano-transduction and ion channel-mediated signaling enables efficient cell migration through confining spaces.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(24)00001-1
