BRCA1-mediated DNA recombination repair and tumor suppression

BRCA1 is dispensable for end resection at replication-coupled double-strand breaks (DSBs) but stimulates processing of replication-independent DSBs. 

BRCA1 promotes RAD51 assembly downstream of end resection.

Canonical BRCA1/RAD51-dependent homologous recombination is essential for tumor suppression.

Loss of 53BP1 enables alternative BRCA1-independent RAD51 assembly.

Alternative BRCA1-independent RAD51 assembly supports tissue development but is not sufficient for tumor suppression.

https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00112-6

https://sciencemission.com/BRCA1-mediated-DNA-recombination-repair