How intestinal E. coli promotes profibrotic macrophages in Crohn’s disease
Intestinal fibrosis is a significant complication of IBD.
The researchers reveal that intestinal E. coli production of the metallophore Ybt sequesters zinc and stabilizes nuclear HIF-1a in macrophages, promoting profibrotic gene expression.
HIF-1a+ macrophages are abundant in fibrotic strictures of human CD patients, where they mark sites of disease.
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00443-8
https://sciencemission.com/E.-coli-promotes-profibrotic-macrophages-in-Crohn%E2%80%99s-disease
