Early-life stress neurobiology
Although early-life stress is a risk factor for cognitive and mental health disorders, understanding of what is perceived as stressful by the developing brain, what aspects of stress influence brain maturation, what developmental ages are particularly vulnerable to stress are incomplete.
In addition the molecules mediate the effects of stress on brain operations, and how transient stressful experiences can lead to enduring emotional and cognitive dysfunctions is unclear.
The researchers in this review discuss these themes, highlight the challenges and progress in resolving them, and propose new concepts and avenues for future research.
